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There was a slight increase in the incidence of cervical and uterine leiomyomas and uterine leiomyosarcomas in miceIn ratsthere was a slight increase in malignant tumors of the cervix and uterus and interstitial cell adenomasThe occurrence of tumors in female rodents may be related to the prolonged suppression of prolactin secretion because prolactin is needed in rodents for the maintenance of the corpus luteumIn the absence of prolactinthe estrogen/progesterone ratio is increasedthereby increasing the risk for uterine tumorsIn male rodentsthe decrease in serum prolactin levels was associated with an increase in serum luteinizing hormonewhich is thought to be a compensatory effect to maintain testicular steroid synthesisSince these hormonal mechanisms are thought to be species-specificthe relevance of these tumors to humans is not known.
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